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KMID : 0380020040190050385
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Korean Journal of Biotechnology and Bioengineering
2004 Volume.19 No. 5 p.385 ~ p.389
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Enzymatic Synthesis of Sorbitan Methacrylate -Effect of Reaction Temperature and Acyl Donor-
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Jeong Gwi-Taek
Park Eun-Soo
Byun Ki-Young
Lee Hye-Jin
Kim In-Hong
Cho Young-Il
Kim Hae-Sung
Song Yo-Soon
Kim Do-Hyung
Ryu Hwa-Won
Lee Woo-Tae
Sunwoo Chang-Shin
Park Don-Hee
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Abstract
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In this research, the chemo-enzymatic synthesis of sorbitan methacrylate was investigated to optimize reaction conditions. Firstly, sorbitan was manufactured by sorbitol cyclic reaction in the presence of p-toluenesulfonic acid (p-TSA) as catalyst material. Secondly, sorbitan methacrylate was synthesized by immobilized lipase Novozyme 435 with acyl donors in t-butanol. As a result of enzymatic synthesis of sorbitan methacrylate, the conversion yield reached about in the condition of initial sorbitan conc. 50 g/L, enzyme content (w/v) , molar ratio 1:3, reaction temperature 50^{circ}C and reaction time 42 hrs using methyl methacrylate as acyl donor. Comparing with acyl donors and reaction temperature, the conversion yield reached about 18, 65 and with methacrylic acid, methyl methacrylate and vinyl methacrylate as acyl donor, respectively. And optimum reaction temperature was 60, 50, and 50^{circ}C, respectively
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KEYWORD
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Sorbitan methacrylate, acyl donor, novozyme 435, reaction condition
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